Synthetic glutathione peroxidase mimics: Effect of nucleophilicity of the aryl thiol cofactor on the antioxidant activity
نویسندگان
چکیده
Catalytic activity of a series of potent amideand amine-based organoselenium compounds are studied in the presence of various aromatic thiols having electron donating and electron withdrawing substituents on the phenyl ring. This study suggests that the antioxidant activities of the synthetic GPx mimics can be significantly increased by the incorporation of a suitable electron donating group on the phenyl ring of an aromatic thiol.
منابع مشابه
Evaluation of hydroalcoholic extract of Thyme on malondialdehyde, thiol, and glutathione peroxidase concentration in the Parkinson's model induced by 6-hydroxydopamine in adult male rats
Background: Parkinson's disease (PD) is a neuropathologic disorder caused by dopaminergic neurons degeneration in the dense part of the substantia nigra. Objective: The present study, designed to evaluate the effect of hydroalcoholic extract of thyme on malondialdehyde (MDA), thiol, and glutathione peroxidase (GPX) concentration in the PD induced by 6-hydroxydopamine in an animal model. Methods...
متن کاملA review of structural properties, metabolic function and measurement of peroxidase activity
The production of reactive oxygen species occurs during the natural metabolism of oxidative-breathing cells. Among reactive oxygen species, hydrogen peroxide is more dangerous to cell life due to its long half-life, but it is meanwhile an important regulatory molecule in redox signaling in living things. Peroxidases are one of the key antioxidant enzymes that are widely distributed in nature an...
متن کاملγ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor
Reactive oxygen species regulate redox-signaling processes, but in excess they can cause cell damage, hence underlying the aetiology of several neurological diseases. Through its ability to down modulate reactive oxygen species, glutathione is considered an essential thiol-antioxidant derivative, yet under certain circumstances it is dispensable for cell growth and redox control. Here we show, ...
متن کاملاثر نیترات پتاسیم بر فعالیت آنزیمهای آنتیاکسیدان در مرحله جوانهزنی بذور زوال یافته ماریتیغال
Seed aging increases activity of reactive oxygen molecules and antioxidant enzymes have a key role against increased oxidative stress which is caused by free radicals. Effect of seed priming on increasing of these enzymes activity and its impacts on seed germination characteristics of deteriorated milk thistle seeds was studied in University of Mohaghegh Ardabili in 2013. Factoral experiment ba...
متن کاملP-2: Study The Effect of Oral Zinc Supplementation on Thiol Oxido-Reductive Index in Spermatozoa of Patients with Asthenospermia
Background: There are several causes leading to male infertility, like oxidative stress, and nutritional deficiency of trace elements i.e., selenium and zinc. The Zinc is the following only to iron as the most abundant element in the body. Although, Zinc is found in red meat, white meat, fish, and milk; the World Health Organization (WHO) approximates that one-third of world population is defic...
متن کامل